OUR SCIENCE
Using science to transform the
lives of patients living with
rare neuroendocrine diseases
Using science to transform the
lives of patients living with
rare neuroendocrine diseases
At Rhythm, we are dedicated to discovering therapies for rare neuroendocrine diseases. Our science is focused on developing therapies for patients with hyperphagia (pathological, insatiable hunger) and obesity caused by a disrupted melanocortin-4 receptor (MC4R) pathway.
The MC4R Pathway
The MC4R pathway in the hypothalamus is a key signalling pathway responsible for regulating hunger, satiety and energy expenditure, which consequently affects body weight.1
Therapeutic Areas
We are developing therapies to re-establish the function of the MC4R pathway to treat rare MC4R pathway diseases, including Bardet-Biedl syndrome and acquired hypothalamic obesity.
Our approach to developing treatments is built upon our foundational understanding of the MC4R pathway.
Craving Answers?
If you would like to learn more about the symptoms or diagnosis of rare MC4R pathway diseases, please visit:
Path4HCPs
If you are a healthcare professional based outside of the US and would like to discover more about the MC4R pathway, rare MC4R pathway diseases and their management, visit our healthcare professional website:
References
- 1.
Fonseca ACP, et al. J Diabetes Complications. 2017;31(10):1549–1561